Jeanine Áñez is the second woman in Bolivia's history to attain the presidential office, after Lidia Gueiler Tejada.
Before being sworn in as head of state, Áñez served as second vice-president of the Bolivian Senate. Although the Political Constitution of the State does not contemplate the second vice-presidency of the Senate to assume the presidency of the country, her ascension was formally endorsed by the Plurinational Constitutional Tribunal two days after the resignation of Evo Morales, declaring that it was ipso facto, in accordance with the precedent established by Constitutional Declaration 0003/01 of July 31, 2001. On January 24, 2020, she announced his candidacy for the presidency in the 2020 elections for the political alliance "Juntos"; but on September 17 renounced her candidacy in order to "avoid dispersing the vote of the anti-MAS bloc". Her term of office ended on November 7, 2020 when she transferred to Luis Arce Catacora.
On June 10, 2022, she was sentenced to 10 years in prison for the crimes of "breach of duties" and "resolutions contrary to the Constitution", by the First Anticorruption Sentencing Court of La Paz.
Through social networks, Áñez had issued comments towards indigenous peoples that have been described as "racist" by The Guardian, "anti-indigenous" by Agence France-Press, and "provocative" by The New York Times. On Twitter, Áñez called the Aymara people’s New Year celebration "satanic" and said that "no one can replace God," and implied that Indigenous people were not authentically Indigenous because they wore shoes.